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KMID : 1007520110200010267
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Food Science and Biotechnology
2011 Volume.20 No. 1 p.267 ~ p.271
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Immunosuppressive Activities of Water-soluble Barley β-Glucan on Alloantigen Reactive Cell Proliferation and Cytotoxicity
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Ryu Deok-Seon
Kim Seon-Hee
Oh Seung-Min
Lee Hyeong-Seon
Jeong Jae-Han
Kim Soo-Hwan
Lee Dong-Seok
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Abstract
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In this study, we investigated the immunosuppressive effects of water-soluble barley β-glucan (BP) in mouse immune cells. The BP was prepared from barley (Hordeum vulgare), and it suppressed the proliferation of splenocytes stimulated with concanavalin A (Con A), interleukin-2 (IL-2), and alloantigenic splenocytes in a dose-dependent manner (0.25, 0.5, and 1mg/mL). Furthermore, the death-inducing activities of cytotoxic T lymphocytes (CTLs) and lymphokine-activated killer cells (LAKs) in alloantigen-reactive splenocytes were significantly suppressed by more than 50%. Also, the production of IL-2 in the splenocytes decreased. These results suggest that these barley-originated polysaccharides can be used as potential immunosuppressive agents.
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KEYWORD
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Hordeum vulgare, water-soluble barley β-glucan, immunosuppressive activity, cell proliferation, cell cytotoxicity
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